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American Society of Microbiology ABMM Sample Questions:

1. A clinical microbiology laboratory is performing quality control on antimicrobial susceptibility testing. The zone diameter for Escherichia coli ATCC 25922 tested against ciprofloxacin is consistently smaller than the acceptable range published by CLSI. The MOST likely cause of this discrepancy is:

A) Inoculation with a bacterial suspension that is too dense
B) Incubation at an incorrect temperature
C) All of the above
D) Use of expired antibiotic disks

2. A research laboratory is investigating the mechanism of action of a novel antiviral compound that inhibits the replication of a specific RNA virus. They find that the compound binds directly to the viral RNA-dependent RNA polymerase, preventing its elongation activity. This mechanism is most similar to that of:

A) Oseltamivir
B) Acyclovir
C) Ribavirin
D) Interferon-beta

3. A patient with a history of valvular heart disease undergoes a dental procedure and subsequently develops a bloodstream infection with Streptococcus mutans. This organism gains access to the bloodstream primarily due to:

A) Formation of a protective biofilm on the teeth.
B) Production of potent extracellular enzymes.
C) Transient bacteremia resulting from the procedure.
D) Active invasion of the oral mucosa.

4. A traveler returning from sub-Saharan Africa presents with cyclical fevers, chills, and sweats. A Giemsa- stained peripheral blood smear reveals multiple ring forms within red blood cells, some applique forms, and occasional banana-shaped gametocytes. No Schüffner's dots or red blood cell enlargement is observed. Which Plasmodium species is the most likely cause?

A) Plasmodium malariae
B) Plasmodium falciparum
C) Plasmodium ovale
D) Plasmodium vivax

5. A clinical microbiology laboratory is preparing to validate a new molecular assay for the detection of methicillin-resistant Staphylococcus aureus (MRSA). To assess the positive predictive value (PPV) of the assay, they need to know:

A) The number of true positive results divided by the total number of positive test results.
B) The number of true positive results divided by the total number of true positive and false negative results.
C) The number of true negative results divided by the total number of negative test results.
D) The number of true negative results divided by the total number of true negative and false positive results.

Solutions: